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Gastrointestinal Pilot Study Seeks to Prevent Gastric Cancer

January 22, 2016

group picture
Front row, Kevin Fukushima, Ruby Mizue, Paul Mizue, Doris Watanabe, May Hamamoto, Florence Sato, Rose Kume Second row, Dyan Kleckner, Liam Mizue, Reid Mizue, Karen Watanabe, Allyson Kume Third row, Glenn Fukiushima, Halbert Ochiae, Charlene Ochiae, Paul Kawaguchi, Dr. James Turkson, Dr. Patricia Blanchette Fourth row, Jimmy Rhymer, Dr. Joe Ramos,  Dr. Scott Kuwada, Dr. Jerris Hedges, Trish Kume, Stewart Kum

The Masami Horio Memorial Fund awards research that could potentially identify people who might benefit from preventative gastric cancer screening

Paul and Ruby Mizue
The Masami Horio Memorial Fund awarded $100,000 to Scott Kuwada, MD, a professor in the Clinical and Translational Research Program at the University of Hawai‘i Cancer Center for his gastrointestinal (GI) cancer pilot study. 

“Being awarded the Masami Horio grant to study gastric cancer is special for me since I too share a personal family connection to gastric cancer here in Hawai‘i. Both of my grandfathers were second generation Japanese, and, one died from gastric cancer and the other from colon cancer,”

- Dr. Kuwada.

GI Cancer Pilot Study

Dr. Kuwada along with other collaborators recently discovered that a rare form of gastric cancer called gastrointestinal stromal tumor (GIST) occurs much more frequently in Asians than whites in Hawai‘i, and, is strongly associated with Helicobacter pylori infection. 

Prior studies at the UH Cancer Center revealed that the higher risk for gastric cancer in early Japanese immigrants in Hawai‘i was due to Helicobacter pylori infection in their stomachs, which was acquired during their childhoods in Japan. 

The grant will be used to identify novel molecular risk factors for gastric cancers, which could be used to identify individuals who might benefit from gastric cancer screening. “We intend to further develop evidence that there should be a gastric cancer screening program for individuals at higher risk for gastric cancers,”

- Dr. Kuwada.

“We give great thanks to the family for their generous contribution to help us build UH Cancer Center investigators who will focus on curing the type of cancer that has affected their family as well as many others in Hawai‘i. These funds are very important because they help early-stage studies have a chance for national funding in the future,”

- Dr. Jerris Hedges, dean of the John A. Burns School of Medicine and interim director of the Cancer Center.

Masami Horio Memorial Fund

Ruby Mizue was the beneficiary of a bequest from her uncle and aunt Masami and Nobuye Horio. Ruby and her husband Paul Mizue decided to memorialize her aunt with a scholarship endowment at UH Leeward Community College and an expendable gift to the UH Cancer Center.

“The decision to establish a scholarship fund and to support cancer research in memory of my uncle and aunt seemed fitting memorials for them as they had no children of their own,”

- Mizue

The purpose of the Fund is to provide a pilot project award for a UH Cancer Center research project related to GI cancer research with a preference for stomach cancer research.

“As a sansei, or third generation Japanese-American, I have been the privileged recipient of the values and sacrifices of my grandparents, parents, and loving aunts and uncles,”

- Mizue.

“Although these gifts will be funded entirely by proceeds from their estate, they are also established with deep gratitude and appreciation for the generations of family who preceded me and enabled my family to enjoy the benefits and privileges of our life in America.”

The UH Cancer Center has many dedicated funds for specific cancer-related research projects, such as those focusing on liver, breast, pancreatic and ovarian cancers.

If you would like to learn how you can support UH students and programs like this, please contact us at 808-956-8700 or send us a message.